{
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  "Title": "Automatic Generation of Initial Estimates for Population\nPharmacokinetic Modeling",
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  "Authors@R": "c(person(\"Zhonghui\",\"Huang\", role = c(\"aut\", \"cre\"), email = \"huangzhonghui22@gmail.com\"),\nperson(\"Joseph\", \"Standing\", role = \"ctb\", email = \"j.standing@ucl.ac.uk\"),\nperson(\"Matthew\", \"Fidler\", role = \"ctb\", email = \"matthew.fidler@gmail.com\"),\nperson(\"Frank\", \"Kloprogge\", role = \"ctb\", email = \"f.kloprogge@ucl.ac.uk\"))",
  "Description": "Provides automated methods for generating initial\nparameter estimates in population pharmacokinetic modeling. The\npipeline integrates adaptive single-point methods, naive pooled\ngraphic approaches, noncompartmental analysis methods, and\nparameter sweeping across pharmacokinetic models. It estimates\nresidual unexplained variability using either data-driven or\nfixed-fraction approaches and assigns pragmatic initial values\nfor inter-individual variability. These strategies are designed\nto improve model robustness and convergence in 'nlmixr2'\nworkflows. For more details see Huang Z, Fidler M, Lan M, Cheng\nIL, Kloprogge F, Standing JF (2025)\n<doi:10.1007/s10928-025-10000-z>.",
  "License": "GPL (>= 3)",
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  "Repository": "https://ucl-pharmacometrics.r-universe.dev",
  "Date/Publication": "2026-06-08 18:33:48 UTC",
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  "Author": "Zhonghui Huang [aut, cre],\nJoseph Standing [ctb],\nMatthew Fidler [ctb],\nFrank Kloprogge [ctb]",
  "Maintainer": "Zhonghui Huang <huangzhonghui22@gmail.com>",
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      "title": "Approximate volume of distribution from observed Cmax",
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    },
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    },
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    },
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    },
    {
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      "title": "Fit oral pharmacokinetic data to a two-compartment model",
      "topics": [
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      ]
    },
    {
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    },
    {
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      "title": "Fit oral pharmacokinetic data to a three-compartment linear elimination model",
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    },
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    },
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      "page": "ka_wanger_nelson",
      "title": "Calculate the absorption rate constant using the Wagner-Nelson method",
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      "title": "Mark dose number",
      "topics": [
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    },
    {
      "page": "metrics.",
      "title": "Calculate metrics for model predictive performance evaluation",
      "topics": [
        "metrics."
      ]
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    {
      "page": "nmpkconvert",
      "title": "Expand additional dosing (ADDL) records for pharmacokinetic analysis",
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    },
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      "title": "Control settings for pooled data analysis",
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    },
    {
      "page": "print.getPPKinits",
      "title": "Print method for 'getPPKinits' objects",
      "topics": [
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    },
    {
      "page": "processData",
      "title": "Process time–concentration dataset for pharmacokinetic analysis",
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    {
      "page": "run_graphcal",
      "title": "Run graphical analysis of pharmacokinetic parameters",
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    {
      "page": "run_ka_solution",
      "title": "Estimate the absorption rate constant using pointwise methods",
      "topics": [
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      "page": "run_pooled_nca",
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    {
      "page": "run_single_point",
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      "page": "run_single_point_base",
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      "page": "run_single_point_extra",
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