Type: Package
Package: nlmixr2autoinit
Title: Automatic Generation of Initial Estimates for Population
        Pharmacokinetic Modeling
Version: 1.0.1
Authors@R: c(person("Zhonghui","Huang", role = c("aut", "cre"), email = "huangzhonghui22@gmail.com"),
   person("Joseph", "Standing", role = "ctb", email = "j.standing@ucl.ac.uk"),
   person("Matthew", "Fidler", role = "ctb", email = "matthew.fidler@gmail.com"),
   person("Frank", "Kloprogge", role = "ctb", email = "f.kloprogge@ucl.ac.uk"))
Description: Provides automated methods for generating initial
        parameter estimates in population pharmacokinetic modeling. The
        pipeline integrates adaptive single-point methods, naive pooled
        graphic approaches, noncompartmental analysis methods, and
        parameter sweeping across pharmacokinetic models. It estimates
        residual unexplained variability using either data-driven or
        fixed-fraction approaches and assigns pragmatic initial values
        for inter-individual variability. These strategies are designed
        to improve model robustness and convergence in 'nlmixr2'
        workflows. For more details see Huang Z, Fidler M, Lan M, Cheng
        IL, Kloprogge F, Standing JF (2025)
        <doi:10.1007/s10928-025-10000-z>.
License: GPL (>= 3)
URL: https://ucl-pharmacometrics.github.io/nlmixr2autoinit,
        https://github.com/ucl-pharmacometrics/nlmixr2autoinit
BugReports: https://github.com/ucl-pharmacometrics/nlmixr2autoinit/issues
Depends: nlmixr2data, R (>= 4.0)
Imports: nlmixr2, nlmixr2est, rxode2, dplyr, tidyr, crayon, purrr,
        knitr, magrittr, progressr, tibble, vpc
Encoding: UTF-8
Language: en-US
NeedsCompilation: no
Roxygen: list(markdown = TRUE)
Suggests: testthat (>= 3.0.0), progress, rmarkdown
VignetteBuilder: knitr
Config/testthat/edition: 3
Config/testthat/parallel: true
Config/roxygen2/version: 8.0.0
Config/pak/sysreqs: cmake libfontconfig1-dev libfreetype6-dev
        libgmp3-dev make libicu-dev libpng-dev libuv1-dev libmpfr-dev
        libssl-dev libx11-dev zlib1g-dev
Repository: https://ucl-pharmacometrics.r-universe.dev
Date/Publication: 2026-06-09 11:02:43 UTC
RemoteUrl: https://github.com/ucl-pharmacometrics/nlmixr2autoinit
RemoteRef: HEAD
RemoteSha: 30e48b0acdd4fdf324935149e2a6263a8437e022
Packaged: 2026-10-13 10:52:50 UTC; root
Author: Zhonghui Huang [aut, cre],
  Joseph Standing [ctb],
  Matthew Fidler [ctb],
  Frank Kloprogge [ctb]
Maintainer: Zhonghui Huang <huangzhonghui22@gmail.com>