# -------------------------------------------- # CITATION file created with {cffr} R package # See also: https://docs.ropensci.org/cffr/ # -------------------------------------------- cff-version: 1.2.0 message: 'To cite package "nlmixr2autoinit" in publications use:' type: software license: GPL-3.0-or-later title: 'nlmixr2autoinit: Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling' version: 1.0.1 doi: 10.32614/CRAN.package.nlmixr2autoinit abstract: Provides automated methods for generating initial parameter estimates in population pharmacokinetic modeling. The pipeline integrates adaptive single-point methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter sweeping across pharmacokinetic models. It estimates residual unexplained variability using either data-driven or fixed-fraction approaches and assigns pragmatic initial values for inter-individual variability. These strategies are designed to improve model robustness and convergence in 'nlmixr2' workflows. For more details see Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025) . authors: - family-names: Huang given-names: Zhonghui email: huangzhonghui22@gmail.com repository: https://ucl-pharmacometrics.r-universe.dev repository-code: https://github.com/ucl-pharmacometrics/nlmixr2autoinit commit: 9a3dd06993b94cad7c5e90ecce419fadcb1f1c5b url: https://ucl-pharmacometrics.github.io/nlmixr2autoinit date-released: '2026-06-08' contact: - family-names: Huang given-names: Zhonghui email: huangzhonghui22@gmail.com